Ball size or ball mass – what matters in organic mechanochemical
Ball mass is an important parameter that is known to have an influence on the outcome of a mechanochemical reaction induced by ball-milling. A standard way of modifying the ball mass is to change the size of the ball made of the same material. In this case, however, a change in mass is accompanied by a simul Editor’s Collection: Mechanochemistry The Solid State of Pharmaceuticals
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Methods. Cocrystal screening was performed by slurry crystallization. The cocrystals were identified and characterized by powder X-ray diffraction, thermal analysis, and single crystal X-ray diffraction. Different particle sizes of each cocrystal were prepared from organic solutions.
Cocrystal Strategy toward Multifunctional 3D‐Printing
Apr 29, 2020 · Cocrystal Strategy toward Multifunctional 3D‐Printing Scaffolds Enables NIR‐Activated Photonic Osteosarcoma Hyperthermia and Enhanced Bone Defect Regeneration Huijing Xiang State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050 P. R. China
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Creating Cocrystals: A Review of Pharmaceutical Cocrystal
Originally discovered almost a century ago, cocrystals continue to gain interest in the modern day due to their ability to modify the physical properties of solid-state materials, particularly pharmaceuticals. Intensification of cocrystal research efforts has been accompanied by an expansion of the potential applications where cocrystals can offer a benefit. Where once solubility manipulation ...
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The role of pH and dose/solubility ratio on cocrystal
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Complete Cocrystal Formation during Resonant Acoustic Wet
it would be optimal to generate sufﬁcient reaction movement between cocrystal compo-nents. The molecular movement of components during the process was known as a crucial factor to facilitate the cocrystal formation in the mechanistic insight . In this study, in order to facilitate the cocrystal formation, our research group devised
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Cocrystal Pharma to Present at H.C. Wainwright Virtual BioConnect Conference GlobeNewswire Inc. - 1/5/2021 8:00:00 AM: Cocrystal Pharma Selects Lead Compound for Further Development Against Coronaviruses GlobeNewswire Inc. - 12/22/2020 8:30:00 AM: Current Report Filing (8-k) Edgar (US Regulatory) - 12/18/2020 4:31:20 PM
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earnings-and-revenue-growth. It would appear that 5.6% of Cocrystal Pharma shares are controlled by hedge funds. That's interesting, because hedge funds can be quite active and activist.
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Terahertz spectroscopic characterizations and DFT
In case of IND-NIC cocrystal, all the characteristic peaks in its experimental THz spectra are successfully reproduced by DFT-FC calculations. In case of IND-SAC cocrystal, the two obviously observed peaks at 1.09 and 1.32 THz are predicted to be the vibrational modes at 1.23 and 1.50 THz.
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PDF) Synthesis and characterization of a (+)-catechin and L
cocrystal ASC was also prepared through Liquid Assisted Grinding (LAG). Here, LAG was performed by adding a small amount of ethanol during the grinding of the starting materials in an agate ball ...
Cocrystal - Wikipedia
Grinding, both neat and liquid-assisted, is employed to produce cocrystal, e.g., using a mortar and pestle, using a ball mill, or using a vibratory mill. In liquid-assisted grinding, or kneading, a small or substoichiometric amount of liquid (solvent) is added to the grinding mixture.
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Overview :: Cocrystal Pharma, Inc. (COCP
Cocrystal Development Pipeline. Our development programs include a wide variety of serious and/or chronic viral diseases including influenza, COVID-19, hepatitis C and gastroenteritis caused by norovirus.
Pharmaceutical cocrystals: An overview - ScienceDirect
2011. 10. 31. · Pharmaceutical cocrystals are emerging as a new class of solid drugs with improved physicochemical properties, which has attracted increased interests from both industrial and academic researchers. In this paper a brief and systematic overview of pharmaceutical cocrystals is provided, with particular focus on cocrystal design strategies, formation methods, physicochemical property studies ...
Pharmaceutics | Free Full-Text | Complete Cocrystal Formation
The manufacturing of solid pharmaceutical dosage forms composed of cocrystals requires numerous processes during which there is risk of dissociation into parent molecules. Resonant acoustic wet granulation (RAG) was devised in an effort to complete theophylline–citric acid (THPCIT) cocrystal formation during the granulation process, thereby reducing the number of operations. In addition ...
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1D versus 2D cocrystals growth via microspacing in-air
Feb 15, 2019 · Cocrystal growth and characterization of 1D and 2D FTCs. The MAS is applicable to grow a series of different PAH‒1,2,4,5-tetracyanobenzene (TCNB) complexes, e.g., anthracene‒TCNB, pyrene ...
Synthesis and characterization of a (+)-catechin and L
2020. 3. 25. · The cocrystal ASC was prepared also by Liquid Assisted Grinding (LAG). (þ)-catechin (50 mg, 0.172 mmol) and L-(þ)-ascorbic acid (30.3 mg, 0.172 mmol) were grinded in an agate ball miller for 3 h in the presence of a small amount of ethanol (20 ...
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